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Jérôme GUICHEUX
Director, the Regenerative Medicine and Skeleton research centre, INSERM UMR 1229-RMeS, Nantes, France. Director, the Electron Microscopy, Microcharacterization and Functional Morphohistology-imaging core facility-SC3M Scientific Head, French National Research Agency (ANR), evaluation panels “Translational Research in Health” (CE17) and “Regenerative Medicine” (CE52) Coordinator, the French Osteoarthritis INSERM Network-netwOArkContact details
1 place Alexis ricordeau, 44042 Nantes cedex 1, France
- Office
- 2919
- Phone
- 0240412919 (n° interne : 312919)
- Jerome.Guicheux@univ-nantes.fr
- Personal Website
- http://www.rmes.univ-nantes.fr/home/
Taught academic discipline(s)
Regenerative medicine
Physiopathology of osteoarticular tissues
Biology of stem cells
Biomaterials
Research topics
The skeleton is affected by a large number of diseases originating from developmental abnormalities, growth impairment, repair dysfunction, cancer and age-associated loss of function. Among these diseases, I am particularly interested in deciphering the pathogenic mechanisms of degenerative age-associated cartilage diseases including osteoarthritis (OA) and the disc degenerative disease also named discarthrosis (DA). I focus my attention on the role of anti-aging factors, autophagy and senescence in the onset of OA and DA. Thanks to the use of animal models closely mimicking the human disease, we are also trying to identify novel therapeutic targets. Due to the increasing clinical situations where cartilaginous tissues are lost (traumatic defects, congenital diseases..) or compromised (osteoarthritis, discarthrosis..), I am also involved in the development of research programs based on the use of stem cells (mesenchymal and induced pluripotent) and hydrogels for the development of joint-targeting drug delivery systems and cell-based regenerative therapeutics.
Key words: Skeleton, osteoarthritis, disc degenerative disease, stem cells, regenerative medicine, hydrogels, biomaterials-assisted cell therapy.
Activities / Resume
Nantes University School of dental medicine. He was a research associate in the internal medicine and
rheumatology department of the University Medical Center of Geneva (Switzerland) from 1997 to 2001.
He was finally recruited as a tenured junior research scientist (CR) by the French national institute for
health and medical research (INSERM) and assigned to the Nantes University in 2001. JG has been
promoted and appointed INSERM junior Research Director (DR2)/full professor in 2008 and senior
Research Director (DR1)/Full professor in 2019; He is currently director of the INSERM research Centre
RMES « Regenerative Medicine and Skeleton » (130 pp, INSERM UMRS 1229, Nantes, France) and the
scientific director of the SC3M core facility (electron Microscopy, Microcharacterization and functional
Morpho-histology and imaging) of the François Bonamy Health Federative Research Institute.
JG is the national coordinator of the Inserm French network dedicated to peripheral and spine OA
(netwOArk). JG is also a board member of Regenerate-Biospine, a member of the Translational Research
Committee of the International Cartilage Regeneration and Joint Preservation Society (ICRS), a member
of the research subcommittee for basic and translational research of The European Alliance of
Associations for Rheumatology (EULAR), the french delegate to the management committee of the
COST-funded osteoarthritis European network (COST EU-netwOArk), a visitation committee Board
member of the Dutch Arthritis Society (Reumanederland) and was a member of the board of directors of
the Osteoarthritis Research Society International (OARSI, 2016-2022).
JG has secured more than 100 research contracts, coordinated 5 pluri-annual programs from the French
national research agency (ANR) and served as coordinator and WP/task leader in several European
grants from FP7, FP8 and H2020. He has authored (updated 1st April 2022) more than 215 indexed
publications (ISI web of knowledge H-index 56 and total citations 8760; google scholar H-index 66, i10
index 161 and total citations 12511) and 9 patents and gave 120 invited lectures.
His research focuses on the pathophysiology of osteoarthritis and disc degenerative disease and the
regenerative medicine of skeletal tissues including bone, articular cartilage and intervertebral disc. JG
has notably contributed to strengthen the relevance of stem cells (mesenchymal stem cells and induced
pluripotent stem cells) and biomaterials (polysaccharide-based hydrogels and calcium phosphate-based
bone biomaterials) for the regeneration of osteoarticular tissues. ISI WOK Researcher ID F-7767-2013;
ORCID 0000-0003-2754-3024.